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FDA Advisory Panel Recommends Against Approval of Merck's NDA for Non ...
HMG-CoA reductase inhibitors interfere with cholesterol synthesis and as such might theoretically blunt adrenal and/or gonadal steroid production. Results of clinical trials with drugs in this class have been inconsistent with regard to drug effects on basal and reserve steroid levels. However, clinical studies have shown that lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce basal plasma testosterone concentration. Another HMG-CoA reductase inhibitor has been shown to reduce the plasma testosterone response to HCG. In the same study, the mean testosterone response to HCG was slightly but not significantly reduced after treatment with lovastatin 40 mg daily for 16 weeks in 21 men. The effects of HMG-CoA reductase inhibitors on male fertility have not been studied in adequate numbers of male patients.
Johnson wins second Daytona 500 pole as Hendrick team rolls on
DAYTONA BEACH, Fla. (AP) - The Hendrick Motorsports juggernaut just keeps on rolling. Reigning NASCAR champion Jimmie Johnson won his second Daytona 500 pole less than 24 hours after new Hendrick teammate Dale Earnhardt Jr. took the checkered flag in the non-points Budweiser Shootout. Michael Waltrip, embarrassed last year at Daytona when his then-new team was caught in the post-qualifying inspection using an illegal fuel additive in his Toyota, also had a great run Sunday, taking the outside pole. Only the top two qualifiers locked in starting positions for next week's 50th running of the Daytona 500. Asked if this makes him the favorite to win the 500, Johnson said, "We have to wait until we get out in the draft and see how these cars work.
Sicknote crackdown will hit 30,000 in Hampshire
A Government crackdown on benefits will hit more than 30,000 claimants acorss Hampshire, it has been revealed. From October next year individuals applying for incapacity benefits will be asked to undertake a new test to establish what they are capable of doing, rather than simply having their disabilities measured, Work and Pensions Secretary Peter Hain said yesterday. The new regime, which will initially cover only new claimants, will eventually be imposed on all those receiving incapacity support. As of May this year there were more than 30,000 such people in south west Hampshire - including nearly 10,000 in Southampton. The harder test will assess claimants' abilities to perform certain work-related tasks, such as using a computer keyboard and mouse.
Wild Card -- Tuesday PM
Spectators at the annual Dayton Days parade in tiny Dayton, Wash., got more than they bargained for last weekend when a team of horses bolted, according to the Walla Walla Union Bulletin, here. 5. Dave Wiegand, a 30-year-old Portland mortgage underwriter was "King of the Hill" after beating 17 or 20 players in the "Scrabble in Seattle" tournament here. 6. IMHO-NW: Jamie Tobias Neely/SR (Passing judgment on Mayor Jim West), Robert L. Jamieson Jr./PI (Remembering dead Iraqis, too), Jim Moore/PI (Scrabble extravaganza), D.F. Oliveria/SR (Monday Huckleberries column), and Coeur d'Alene Press (North Idaho wrestles with loss). *Olympian reader poll: "Have the Republicans proven their case in the gubernatorial election trial: Yes -- 52.1%, No -- 47.9%. *Spokane Mayor Jim West predicts on national TV he'll survive scandal here.
Dr. Robin Ashinoff recommends using a home humidifier to help prevent ...
Intensive fluids deliver nutrients to winter-weather-stressed skin. For example, the Vagheggi Vitamin C-Fluid emulsions protect, tone and firm, making complexions look gradually clearer and more radiant. Active ingredients include whole extract of sweet orange, macademia oil, jojoba oil and Vitamin E acetate ($45 to 100). B. Kamins cosmeceuticals focus on a range of skin conditions, with emphasis on sensitive, menopause, rosacea and extra-dry skin types ($30 to 150). Available at Cascata the Spa, 60 South St., Morristown.
Bobbi Brown Hydrating Face Cream replenishes daily moisture loss. Formulated with algae extract, a hydrating botanical and kukui nut oil, a skin-softening natural extract ($45). Available at Nordstroms, Garden State Plaza and The Mall at Short Hills.
Dr. Jeannette Graf's Skin Perfect Microdermabrasion Kit is an in-home, deep-cleaning set that includes a cleanser to soothe, soften and moisturize; microdermabrasion cream peel to tone, balance and hydrate and Night Revive Complex, a long-lasting highly emollient formula designed to fight the appearance of fine lines and wrinkles ($34.50).
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